TITRATABLECONTROLof blood pressure reduction with CLEVIPREX® (clevidipine)
CLEVIPREX—a dihydropyridine calcium channel blocker—can provide blood pressure (BP) reduction in the perioperative setting and in acute severe hypertension cases.
Non–weight-based dosing regimen that is independent of renal or hepatic function1
CLEVIPREX is a low-volume, non–weight-based dosing regimen for individualized, titratable administration.1
CALCULATE DOSING
Proven efficacy in clinical studies
- Over 90% of patients with perioperative hypertension achieved treatment success (≥15% BP reduction from baseline)2,3
- Low rate of overshoot in acute severe hypertension patients in the VELOCITY trial4
BP reduction within minutes
In perioperative patients, CLEVIPREX produces a 4%–5% reduction in systolic blood pressure (SBP) within 2–4 minutes of initiation. An approximately 1–2 mg/hr increase will generally produce an additional 2–4 mmHg decrease in systolic pressure.
Demonstrated safety profile
The safety profile of CLEVIPREX was evaluated in multiple clinical trials.1
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References: 1. CLEVIPREX® (clevidipine) Prescribing Information. 2013. 2. Levy JH, Mancao MY, Gitter R, et al. Clevidipine effectively and rapidly controls blood pressure preoperatively in cardiac surgery patients: the results of the randomized, placebo-controlled efficacy study of clevidipine assessing its preoperative antihypertensive effect in cardiac surgery-1. Anesth Analg. 2007;105(4):918-925. 3. Singla N, Warltier DC, Gandhi SD, et al. ESCAPE-2 Study Group. Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial. Anesth Analg. 2008;107(1):59-67. 4. Pollack CV, Varon J, Garrison NA, Ebrahimi R, Dunbar L, Peacock FW. Clevidipine, an intravenous dihydropyridine calcium channel blocker, is safe and effective for the treatment of patients with acute severe hypertension. Ann Emerg Med. 2009;53(3):329-338.
